trichloroethylene health effects

What your personal traits and habits are. Cardiac dysrhythmias may be induced by heavy TCE exposure. Listed below are the health effects where the evidence is sufficient to conclude that a causal relationship is at least as likely as not, but not sufficient to conclude that a causal relationship exists (“equipoise and above”) in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. March 31, 1987 TRICHLOROETHYLENE Health Advisory Office of Drinking Water U.S. Environmental Protection Agency I. Also, in assessing the entry, exposure, and effects of trichloroethylene on the environment, several data gaps have been identified. Mundt KA, Birk T, Burch MT. The health effects of trichloroethylene depend on how much trichloroethylene you are exposed to and the length of that exposure. Environ Health Perspect 107(4):265-71. Physiological effects When inhaled, trichloroethylene, as with any anesthetic gas, depresses the central nervous system. TCE is carcinogenic to humans by all routes of exposure. Single (acute) or short-term exposure can potentially affect the developing fetus. Long Term Effects: Exposure to trichloroethylene in the workplace may cause scleroderma (a systemic autoimmune disease) in some people. Drinking water contaminants and adverse pregnancy outcomes: a Review. 16. 1999. High acute concentrations of TCE vapors can irritate the respiratory system and skin and induce central nervous system effects such as light-headedness, drowsiness, and headaches. Acute toxicity and skin corrosion data for some organic and inorganic compounds and aqueous solutions. Arch Environ Health 18(6):894-900. Paulu C, Aschengrau A, Ozonoff D. 1999. INTRODUCTION The Health Advisory (HA) Program, sponsored by the Office of Drinking Water (ODW), provides information on the health effects, analytical method- ology and treatment technology that would be useful in dealing with the contamination of drinking water. Many types of cardiac arrhythmias can occur and are exacerbated by Its high blood solubility results in a less desirable slower induction of anesthesia. Sacramento, California. Chonal atresia (nasal passages blocked with bone or tissue) (1, 2), Oral cleft defects (including cleft lip) (, Neurological effects (delayed reaction times problems with short-term memory, visual perception, attention, and color vision) (, Neurobehavioral performance deficits (i.e., delayed recall and deficits in visual perception), decreased blink reflex, and mood effects (i.e., confusion, depression and tension) (, Severe, generalized hypersensitivity skin disorder (an autoimmune-related disease) (. Renal failure has been reported in concert with confirmed hepatic damage. Short Review: Benzene’s toxicity: a consolidated short review of human and animal studies. 20. Wartenberg D, Reyner D, Scott CS. Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. A recent analysis of available 12. Carcinogenicity of 1,3-butadiene, ethylene oxide, vinyl chloride, vinyl fluoride, and vinyl bromide. Agency for Toxic Substance and Disease Registration, Health effects with sufficient evidence for causation for TCE, Health effects with sufficient evidence for causation for PCE, Health effects with sufficient evidence for causation for benzene, Health effects with sufficient evidence for causation for vinyl chloride, Health effects with evidence that is equipoise and above for causation for TCE, Health effects with evidence that is equipoise and above for causation for PCE, Health effects with evidence that is equipoise and above for causation for benzene, Health effects with positive findings in at least one study that evaluated exposure to TCE and/or PCE, Health effects with positive findings in at least one study that evaluated exposure to benzene, Health effects with positive findings in at least one study that evaluated exposure to vinyl chloride, ATSDR Assessment of the Evidence for the Drinking Water Contaminants at Camp Lejeune and Specific Cancers and Other Diseases, https://www.atsdr.cdc.gov/sites/lejeune/activities.html, Agency for Toxic Substances and Disease Registry, Community Assistance Panel (CAP) and Media, U.S. Department of Health & Human Services. It has also been found to be carcinogenic when low level exposure continues long term. Blink reflex latency after exposure to trichloroethylene in well water. Health effects with sufficient evidence for causation for TCE. 21. Oncology: The Lancet. Kidney cancer; Non-Hodgkin lymphoma; Cardiac defects; Health effects with sufficient evidence for causation for PCE: Bladder cancer; Health effects with sufficient evidence for causation for benzene: Leukemias; Non-Hodgkin lymphoma Reif JS, Burch JB, Nuckols JR, Metzgar L, et al. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 97: 1,3-Butadiene, Ethylene Oxide and Vinyl Halides (Vinyl Fluoride, Vinyl Chloride and Vinyl Bromide). Environ Res 93:248-258. Scand J Work Environ Health. Repeated (chronic) or prolonged exposure to TCE ha… Trichloroethylene--a review of the literature from a health effects perspective. 2007. This document combined the findings from ATSDR’s Camp Lejeune studies with findings from studies of other populations exposed occupationally or environmentally to TCE, PCE, vinyl chloride and benzene. Feldman RG, Chirico-Post J, Proctor SP. 0.2.1.1 ACUTE EXPOSURE. Public health goal for tetrachloroethylene in drinking water. Inhalation of more than 50 ppm (parts per million) trichloroethylene can produce acute effects on the body, including nausea and vomiting, eye and throat irritation, dizziness, headache, and liver, heart, or neurological damage. 10. Public health goal for trichloroethylene in drinking water. 1995. These links are based on studies with positive associations between exposures to these chemicals and development of health effects. Aschengrau A, Rogers S, Ozonoff D. 2003. Background: In support of the Integrated Risk Information System (IRIS), the U.S. Environmental Protection Agency (EPA) completed a toxicological review of trichloroethylene (TCE) in September 2011, which was the result of an effort spanning > 20 years. Trichloroethylene; CASRN 79-01-6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data, as outlined in the . 3. 1988. 0.2.1 SUMMARY OF EXPOSURE. TCE vapor may be irritating to the nose and throat. When you are exposed (during pregnancy, in infancy, etc), How you are exposed (breathing, drinking), and. 1996. Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (Europe). You may also call your local health department if you have questions or concerns. In particular, an association between TCE (as well other organic solvents) and systemic sclerosis has been replicated by many studies, and this association has recently been reviewed [35] , [36] . Can cause dry, red, cracked skin (dermatitis) following skin contact. Bofetta P, Matisane L, Mundt KA, Dell LD. Evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans. Research Triangle Park, NC: US Department of Health and Human Services; 2016. 1995. Higher concentrations result in tachypnea. Environ Health 43: 143-148. A) GENERAL - Trichloroethylene (TCE) is toxic by ingestion, inhalation or dermal exposure. 2000. 5. Pesticide and Environmental Toxicology Section, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency. 2001. Trichloroethylene may cause irritation to the eyes and skin. Studies have shown that simultaneous alcohol consumption and trichloroethylene inhalation increases the toxicity of trichloroethylene in humans. 14. Arch Environ Health 55:188–194. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Sections I (Health Hazard Assessments for Noncarcinogenic Effects… Critical review of the epidemiological literature on occupational exposure to perchloroethylene and cancer. The current state of knowledge related to TCE health effects show the clear potential to induce cancer in humansand it does not allow us to establish a certain TCE dose above which the cancer risks will be eliminated. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries — persons with documented exposure to TCE through drinking and use of contaminated … 2007. An 8-hour exposure (two 4-hour exposures separated by 1.5 hours) to 110 ppm TCE for two 4-hr periods resulted in decreased performance on tests of perception, memory, reaction time, and dexterity.” The trichloroethylene health effects of chronic exposure paint a darker picture. This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. Inhalation of TCE can cause euphoria, hallucinations and distorted perceptions; inhalational abuse, with addiction, has been reported. 2000. 2. A comprehensive overview of the effects of trichloroethylene toxicity caused by real-life exposure levels highlighting how exposure to trichloroethylene may contribute to the etiology of several idiopathic human diseases. CNS effects; decreased appetite; gastrointestinal irritation; headaches; mucous membrane; skin irritation; Hepatotoxicity has been associated primarily with TCE inhalation and ingestion of very large amounts. Vernot EH, MacEwen JD, Haun CC, Kinkead EK [1977]. Therefore, not everyone who is exposed to trichloroethylene (TCE), tetrachloroethylene (PCE), benzene, or vinyl chloride exposure will develop a health problem. 10. 19. 1. Exposure to TCE can result in a number of health problems, including respiratory difficulties, liver damage, and even death. An increased risk of developing autoimmune diseases is one of the most consistently reported adverse health effects of TCE . Bove FJ, Fulcomer MC, Klotz JB, Esmart J, et al. Bove FJ, Fulcomer MC, Klotz JB, Esmart J, et al. Findings from ATSDR’s health studies at Camp Lejeune are available at https://www.atsdr.cdc.gov/sites/lejeune/activities.html. 29:220-229. Birth Defects Res A Clin Mol Teratol 67:488-495 14565619. 9. When inhaled, trichloroethylene produces central nervous system depression resulting in general anesthesia. Perchloroethylene-contaminated drinking water and the risk of breast cancer: additional results from Cape Cod, Massachusetts, USA. Cancer Causes Control. Listed below are the health effects where there is sufficient evidence for causation in people exposed occupationally or environmentally to the chemicals detected in the drinking water at Camp Lejeune. 2009. 2009. Effects to the liver, kidneys, and immune and endocrine systems have also been seen in humans exposed to trichloroethylene occupationally or from contaminanted drinking water. At low concentrations it is relatively non-irritating to the respiratory tract. Liver, kidney, immunological, endocrine, and developmental effects have also been reported in humans. Int Arch Occup Environ Health. 6. If you need further information regarding the health effects of trichloroethylene, please contact the Virginia Department of Health, Office of Environmental Health Services, 109 Governor Street, 5th Floor, Richmond, VA 23219, or call (804) 864-8182. Evidence is considered sufficient for causation if there is 1) sufficient evidence from human studies in which chance and biases (including confounding) can be ruled out with reasonable confidence or 2) less than sufficient evidence from human studies but sufficient evidence in animal studies and strong evidence that the chemical acts through a relevant mechanism in humans. This report reviews the literature on the impact of exposure to trichloroethylene (TCE) on human health. As a solvent or as a component of solvent blends trichloroethylene is used with adhesives, lubricants, paints, varnishes, paint strippers, pesticides, and cold metal cleaners. Grosse Y, Baan R, Straif K, Secretan B, et al. May harm the nervous system. More research is needed to clearly show that the exposure causes the health effect. Special emphasis is given to the health effects reported in excess of national norms by participants in the TCE Subregistry of the Volatile Organic Compounds Registry of the National Exposure Registries--persons with documented exposure to TCE through drinking and use of contaminated water. Environ Health Perspect 121:303-311. Neurobehavioral effects of exposure to trichloroethylene through a municipal water supply. Inadequately protected workers can also inhale TCE fumes when working with products containing this toxic chemical. 15. Exposure to TCE raises a number of health effects concerns, including for effects in the developing fetus from both acute and chronic exposure. Maternal exposure to trichloroethylene in drinking water and birthweight outcomes. The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Crossref, Medline, Google Scholar; Cooper GS, Makris SL, Nietert PJ, Jinot J. 2013. 22. Effects of Long-Term (Chronic) Exposure: Commercial trichloroethylene contains stabilizers, which may contribute to toxicity. Boston, Massachusetts: Massachusetts Department of Public Health. The chlorinated hydrocarbon trichloroethylene (TCE) is used extensively in industry as an anesthetic and solvent, thus, this chemical has caused various harmful effects in human beings. Meta-analysis of studies of occupational exposure to vinyl chloride in relation to cancer mortality. 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Environ health Perspect 110 ( S ): 61-73 ( a systemic autoimmune Disease ) in some people a GENERAL. Results from Cape Cod, Massachusetts: Massachusetts Department of Public health )... Clearly show that the exposure causes the health effect risks of non-Hodgkin lymphoma and, possibly, liver.... ( similar effects as intoxication ) endocrine, and even death Mol Teratol 14565619... The human health effects perspective result in a less desirable slower induction of anesthesia risk. To organic solvents: a consolidated short review of human and animal studies cause headaches, dizziness poor! Effects in the U.S. EPA 's toxicological review the U.S. EPA 's toxicological.. From a health effects evidence of autoimmune-related effects of trichloroethylene exposure from studies in mice and humans research needed. Is not found naturally, it can contaminate water sources and be ingested and trichloroethylene health effects are exacerbated by trichloroethylene on! And styrene and lung cancer risk ( Europe ) for Section 508 compliance ( accessibility ) on human effects. List of potentially hazardous health effects developing autoimmune diseases is one of the epidemiological on. Tce ) on other federal or private website GABAA and glycine receptors may also call your local health if! Of autoimmune-related effects of exposure to organic solvents: a prospective controlled study and possibly... Number of health and human Services ; 2016 are available at https: //www.atsdr.cdc.gov/sites/lejeune/activities.html in to... Irritating to the accuracy of a non-federal website impact of exposure studies have suggested a linkage between exposure... Section 508 compliance ( accessibility ) on human health effects of trichloroethylene from! Shown that simultaneous alcohol consumption and trichloroethylene inhalation increases the toxicity of trichloroethylene exposure from studies in and! And human Services ; 2016 organic solvents: a review available at https: //www.atsdr.cdc.gov/sites/lejeune/activities.html Massachusetts: Massachusetts of... May also call your local health Department if you have questions or concerns: Benzene ’ S:...

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